Aceclofenac 100 mg + Paracetamol 325 mg + Serratiopeptidase 15 mg Tablet

Product Description

• Diclofenac Sodium + Paracetamol + Serratiopeptidase Pharmacology
• Diclofenac Sodium + Paracetamol + Serratiopeptidase
• About Diclofenac Sodium + Paracetamol + Serratiopeptidase
•     N/A
• Mechanism of Action of Diclofenac Sodium + Paracetamol + Serratiopeptidase
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• Pharmacokinets of Diclofenac Sodium + Paracetamol + Serratiopeptidase
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• Onset of Action for Diclofenac Sodium + Paracetamol + Serratiopeptidase
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• Duration of Action for Diclofenac Sodium + Paracetamol + Serratiopeptidase
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• Half Life of Diclofenac Sodium + Paracetamol + Serratiopeptidase
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• Side Effects of Diclofenac Sodium + Paracetamol + Serratiopeptidase
•     N/A
• Contra-indications of Diclofenac Sodium + Paracetamol + Serratiopeptidase
•     N/A
• Special Precautions while taking Diclofenac Sodium + Paracetamol + Serratiopeptidase
•     N/A
• Pregnancy Related Information
•     N/A
• Old Age Related Information
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• Breast Feeding Related Information
•     N/A
• Children Related Information
•     N/A
• Indications for Diclofenac Sodium + Paracetamol + Serratiopeptidase
•     N/A
• Interactions for Diclofenac Sodium + Paracetamol + Serratiopeptidase
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• Typical Dosage for Diclofenac Sodium + Paracetamol + Serratiopeptidase
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• Schedule of Diclofenac Sodium + Paracetamol + Serratiopeptidase
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• Storage Requirements for Diclofenac Sodium + Paracetamol + Serratiopeptidase
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• Effects of Missed Dosage of Diclofenac Sodium + Paracetamol + Serratiopeptidase
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• Effects of Overdose of Diclofenac Sodium + Paracetamol + Serratiopeptidase
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• Diclofenac Sodium
• About Diclofenac Sodium
•     N/A
• Mechanism of Action of Diclofenac Sodium
•     Diclofenac possess analgesic, anti-inflammatory and antipyretic action. It inhibits the enzyme cyclo-oxygenase and there by inhibits the synthesis of Prostaglandins (PGs). It is more potent against cyclo-oxygenase-2 enzyme as compared to other NSAIDs like Indomethacin, Naproxen etc. It reduces intracellular concentrations of free arachidonic acid in leukocyte by altering its release or uptake. .
• Pharmacokinets of Diclofenac Sodium
•     Absorption: Diclofenac sodium is rapidly absorbed after oral administration. It undergoes first pass metabolism and its bioavailability is 50 % only. Distribution: It is distributed in highly protein bound form. Metabolism: Diclofenac sodium is metabolised in the liver. Excretion: Drug and metabolites are primarily excreted in urine and some amount in the bile.
• Onset of Action for Diclofenac Sodium
•     1- 4.5 hours
• Duration of Action for Diclofenac Sodium
•     Hours
• Half Life of Diclofenac Sodium
•     2 hours
• Side Effects of Diclofenac Sodium
•     1.Nausea
•     2.Vomiting
•     3.Anorexia
•     4.Diarrhoea
•     5.Gastrointestinal bleeding
•     6.Abdominal distress
•     7.Constipation
•     8.Flatulence
•     9.Ulceration of the stomach or intestine
•     10.Dyspepsia
•     11.Headache
•     12.Dizziness
•     13. Rash
• Contra-indications of Diclofenac Sodium
•     1.Hypersensitivity to Indomethacin and other Non steroidal anti inflammatory drugs(NSAID)
•     2.Peptic ulcer
•     3.Asthma
• Special Precautions while taking Diclofenac Sodium
•     1.Hepatic impairment
•     2.Renal impairment
•     3.Hypertension
•     4.Blood clotting disorders
•     5.Gastrointestinal diseases
•     6.Proctitis
•     7.Asthma
•     8.Cautioned against driving, operating or activities requiring concentration
•     9.Avoid alcohol
•     10.Heart failure
• Pregnancy Related Information
•     Contraindicated
• Old Age Related Information
•     Use with caution
• Breast Feeding Related Information
•     Contraindicated
• Children Related Information
•     CHILDREN below 14: contraindicated
• Indications for Diclofenac Sodium
• Ankylosing spondylitis
• Acute gout
• Joint disorders e.g. inflammatory disease in joints, crystal deposition in the joints
• Osteoarthritis
• For the relief of pain and inflammation in dental minor surgery and orthopedic
• Dysmenorrhoea
• uvenile chronic arthritis
• Migraine
• Interactions for Diclofenac Sodium
• Lithium & Digoxin : Blood levels of lithium and digoxin increased leading to enhanced efficacy and posible toxicity.
• Diuretics : Inhibits diuretics but efficacy of potassium sparing diuretics enhanced.
• Methotrexate : Toxicity enhanced.
• Salicylates : Efficacy of salicylates reduced.
• Cyclosporine : Increases nephrotoxicity of both agents.
• Hydantoins : Increases serum levels resulting in toxicity.
• Typical Dosage for Diclofenac Sodium
• Adult: 100 - 150 mg / day in 2 - 3 divided doses.
• For the relief of pain, Migraine, Dysmenorrhoea: 150 mg / day in 3 divided doses.
• Osteoarthritis: 50 mg 2 - 3 times daily
• Rheumatoid arthritis: 150 - 200 mg / day in 3 - 4 divided doses.
• Ankylosing spondylitis: 25 mg 4 times daily give an extra dose of 25 mg at bed time if necessary.
• Children Juvenile rheumatoid arthritis: 0.5 - 2 mg / kg body weight / day in divided doses.
• Maximum dose: 3 mg / kg body weight / day in divided doses
• Schedule of Diclofenac Sodium
• Storage Requirements for Diclofenac Sodium
•     Store Diclofenac sodium at room temperature in a tightly closed light resistant container.
• Effects of Missed Dosage of Diclofenac Sodium
•     Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
• Effects of Overdose of Diclofenac Sodium
•     Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal.
• Paracetamol
• About Paracetamol
•     Acetanilide derivative, Non narcotic Analgesic,Antipyretic.
• Mechanism of Action of Paracetamol
•     Paracetamol has analgesic and antipyretic action.
•     It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
•     Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
•     Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
• Pharmacokinets of Paracetamol
•     Absorption: Paracetamol is rapidly and completely absorbed after oral administration.
•     Distribution: It is distributed mostly in the body in unbound form.
•     Metabolism: It is extensively metabolised in the liver.
•     Excretion: Excreted in the urine.
• Onset of Action for Paracetamol
•     30 - 60 minutes
• Duration of Action for Paracetamol
•     6 hours
• Half Life of Paracetamol
•     1-4 hours
• Side Effects of Paracetamol
•     1. Nausea
•     2. Abdominal distress
•     3. Allergic reactions
•     4. Rash
• Contra-indications of Paracetamol
•     1. Hypersensitivity to Paracetamol
• Special Precautions while taking Paracetamol
•     1. Hepatic impairment
•     2. Renal impairment
•     3. Hypertension
• Pregnancy Related Information
•     Use with caution
• Old Age Related Information
•     Use with caution
• Breast Feeding Related Information
•     Use with caution
• Children Related Information
•     Use with caution
•     NEONATES : Contraindicated
• Indications for Paracetamol
•     1. To relieve pain and fever
•     2. Acute gout
•     3. Migraine
• Interactions for Paracetamol
•     Cholestyramine: Reduces absorption of paracetamol.
•     Charcoal: Activated, administered immediately reduces absorption of paracetamol.
•     Domperidone and metochlopramide: Enhance absorption of paracetamol.
•     Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
•     Zidovudine: Effects zidovudine may be decreased.
• Typical Dosage for Paracetamol
•     Adult:
•     500 - 1000 mg in 3 times daily
•     Maximum dose: 4 g / day
•     For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
•     Children:
•     60 mg / kg body weight /day in 4 divided doses.
• Schedule of Paracetamol
•     H
• Storage Requirements for Paracetamol
•     Store at 15-30 degree C in a tightly closed container. Protect from heat and moisture. Keep out of the reach of children.
• Effects of Missed Dosage of Paracetamol
•     Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
• Effects of Overdose of Paracetamol
•     Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or by inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. N-acetylcysteine is the specific antidote for Paracetamol poisoning. Dose: 150 mg /kg body weight as IV infusion over 15 minutes followed by same dose over 20 hours.
•     Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.

Serratiopeptidase

• About Serratiopeptidase
•  A proteolytic enzyme, A powerful anti-inflammatory, anti-edemic.
• Mechanism of Action of Serratiopeptidase
• This anti-inflammatory proteolytic enzyme bind to the alpha-2-macroglobulin in the blood, which helps to mask its antigenicity.Then it is slowly transferred to the site of inflammation. Serratiopeptidase hydrolyze bradykinin, histamine, serotoxin responsible for oedema.It reduces swelling improves microcirculation and expectoration of sputum. Due to this action Serratiopeptidase has anti-inflammatory, antioedemic and fibrinolytic activity and act rapidly on localized inflammation.
• Pharmacokinets of Serratiopeptidase
• Orally absorbed. In the case of enteric coated tablet absorption take place in the intestine. After absorption it is directly enter in to the bloodstream. It is excreted via urine and bile.
• Onset of Action for Serratiopeptidase
• Duration of Action for Serratiopeptidase
•  8 to 10 hrs
• Half Life of Serratiopeptidase

Side Effects of Serratiopeptidase

• Hypersensitivity
• Anorexia
• Gastric discomfort
• Nausea
• Vomiting
• Epistaxis
• Diarrhoea
• Skin rash

Contra-indications of Serratiopeptidase

• Hypersensitivity to this drug
• Blood coagulation disorder
• Special Precautions while taking Serratiopeptidase
• In patients with renal failure or hepatic failure
• Pregnancy Related Information
• Contraindicated
• Old Age Related Information
• Breast Feeding Related Information
•  Contraindicated
• Children Related Information
• Indications for Serratiopeptidase

• Antiinflammatory
• Antiswelling
• Anti- rheumatoid
• To promote transfer of antibiotics to the site of action
• To promote lysis and discharge of sputum and pus
• Bronchitis
• Fibrocystic breast swelling
• Sinusitis
•  Cough
• Laryngitis
• Fibromyalgia
• Emphysema
• Gout

Interactions for Serratiopeptidase
    N/A
Typical Dosage for Serratiopeptidase
    Oral-
    Adults-5 to 10mg tab every 3 times daily.
    10- 30 mg tab /day.
Schedule of Serratiopeptidase
    N/A
Storage Requirements for Serratiopeptidase
    Store below 25 degree Celsius, protect from light and moisture.
Effects of Missed Dosage of Serratiopeptidase
    Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Serratiopeptidase
    Give supportive measures and symptomatic treatment.

Home Delivery for Diclofenac Sodium + Paracetamol + Serratiopeptidase in Your City

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Side Effects of Diclofenac 50mg + Paracetamol 500mg + Serratiopeptidase 10mg:

• GI Disturbances, Nephrotic Syndrome, Epigastric Pain, Nausea, Vomiting, Diarrhoea, Hepatitis, Rash, Pruritus, Wheezing, Bronchospasm, Prolonged Bleeding Time. Potentially Fatal: Bleeding Or Perforation Through Peptic Ulcer, Rarely Blood Dyscrasia Or Anaphylaxis, Acute Renal Failure.
• Drug Interactions of Diclofenac 50mg + Paracetamol 500mg + Serratiopeptidase 10mg:
• Potentiates Potassium-Sparing Diuretics. Reduced Serum Levels Of Salicylates. Potentially Fatal: Increased Levels Of Lithium, Digoxin And Methotrexate.
• Contraindications of Diclofenac 50mg + Paracetamol 500mg + Serratiopeptidase 10mg:
• Hypersensitivity, Active Peptic Ulcer Or GI Bleeding, History Of Allergic Responses To Aspirin Or Other NSAIDs, Acute Porphyria.
• Mechanism of Action of Diclofenac 50mg + Paracetamol 500mg + Serratiopeptidase 10mg:
• Diclofenac Is A NSAID (NSAID). Paracetamol Is An Analgesic And Antipyretic. When Used Together, The Actions Of Paracetamol Set In Earlier And Provides Pain Relief Before The Effects Of Diclofenac Na Set In.
• Special Precautions for Diclofenac 50mg + Paracetamol 500mg + Serratiopeptidase 10mg:
• Analgesic Nephropathy, Renal Or Hepatic Impairment, Hypertension, Cardiac Failure, Bronchospasm, Patients Taking Diuretics And Elderly, Lactatio