Long-term blood circulation problems in the brain (cerebrovascular diseases). There is some evidence that taking citicoline by mouth or injecting citicoline into the vein or muscle might improve memory and behavior in patients with long-term cerebrovascular diseases, such as stroke.
Stroke recovery. Stroke patients who take citicoline by mouth within 24 hours of having the kind of stroke that is caused by a clot (ischemic stroke) are more likely than other ischemic stroke patients to have a complete recovery within 3 months. Stroke patients who receive intravenous (IV) citicoline within 12 hours of having an ischemic stroke and daily thereafter for 7 days also have improved recovery.
Insufficient Evidence for
Alzheimer's disease and other types of dementia. Some evidence suggests that taking citicoline by mouth might improve learning, memory and information processing (cognitive function) in people with mild to moderate Alzheimer's disease.
Lazy eye (amblyopia). Early research suggests that giving citicoline as a shot for 15 days might improve vision in people with a lazy eye.
Bipolar disorder. Early research suggests that taking citicoline does not improve depression or manic symptoms in people with bipolar disorder and cocaine addiction.
Cocaine addiction. Early research suggests that taking citicoline might reduce cocaine use in people with bipolar disorder and cocaine addiction.
Glaucoma. Developing evidence suggests that citicoline might improve vision in some people with glaucoma.
Vision loss due to blockage of the optic nerve (ischemic optic neuropathy).Early research suggests that taking a specific citicoline product (Cebrolux-Tubilux) for 60 days might improve vision in people with ischemic optic neuropathy.
Memory. Early research suggests that taking citicoline might improve memory, learning, and speaking ability in people with brain injury due to trauma. Other research suggests that citicoline might improve some aspects of memory in elderly people.
Muscle strength. Early research suggests that injecting citicoline intravenously (by IV) might improve muscle strength in people recovering from a type of stroke called a cerebral hemorrhage that was not caused by trauma.
Parkinson's disease. Some research shows that giving citicoline as a shot along with usual treatment might improve some of the symptoms of Parkinsons disease, but not shaking (tremor).
Recovery after surgery. Early research suggests that taking citicoline 24 hours before surgery and for 4 days after surgery might reduce symptoms of delirium after surgery in elderly people.
Vascular dementia. Taking citicoline does not seem to improve symptoms in people with vascular dementia.
Attention deficit-hyperactive disorder (ADHD).
Side Effects & Safety
Citicoline is POSSIBLY SAFE when taken by mouth short-term (up to 90 days). The safety of long-term use is not known. Most people who take citicoline don't experience problematic side effects. But some people can have side effects such as trouble sleeping (insomnia), headache, diarrhea, low or high blood pressure, nausea, blurred vision, chest pains, and others.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking citicoline if you are pregnant or breast-feeding. Stay on the safe side and avoid use.