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Duloxetine is used to treat major depressive disorder in adults. It is also used to treat generalÂ generalized anxiety disorderÂ in adults and children who are at least 7 years old.
Duloxetine is also used to treat pain caused by nerve damage in adults with diabetes (diabetic neuropathy).
Do not take this medicine within 5 days before or 14 days after you have used anÂ MAO inhibitor, such asÂ isocarboxazid,Â linezolid,Â methylene blueÂ injection,Â phenelzine,Â rasagiline,Â selegiline, orÂ tranylcypromine.
Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Do not stop using duloxetine without first talking to your doctor.
You should not use duloxetine if you are allergic to it.
Do not take duloxetine within 5 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. A dangerous drug interaction could occur.
Some medicines can interact with duloxetine and cause a serious condition calledÂ serotonin syndrome.Be sure your doctor knows if you also take stimulant medicine, opioid medicine,Â herbal products, or medicine for depression, mental illness,Â Parkinson's disease,Â migraineÂ headaches, serious infections, or prevention ofÂ nausea and vomiting.Â Ask your doctor before making any changes in how or when you take your medications.
To make sure duloxetine is safe for you, tell your doctor if you have ever had:
liver or kidney disease;
a bleeding or blood clotting disorder;
drug addictionÂ or suicidal thoughts.
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using duloxetine. Your family or other caregivers should also be alert to changes in your mood or symptoms.
It is not known whether duloxetine will harm an unborn baby. However, duloxetine may cause problems in a newborn if you take the medicine during the third trimester of pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.
If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of this medicine on the baby.
Duloxetine can pass into breast milk, but effects on the nursing baby are not known. Tell your doctor if you are breast-feeding.
Duloxetine is not approved for use by anyone younger than 18 years old.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes,Â anxiety,Â panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
easy bruising, unusual bleeding;
painful or difficult urination;
a manic episode -Â racing thoughts, increased energy, reckless behavior, feeling extremely happy or irritable, talking more than usual, severe problems with sleep;
liver problems -Â right-sided upper stomach pain, itching, dark urine,Â jaundiceÂ (yellowing of the skin or eyes);
severe skin reaction -Â fever,Â sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Seek medical attention right away if you have symptoms of serotonin syndrome, such as:Â agitation, hallucinations, fever, sweating, shivering,Â fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, orÂ diarrhea.
Older adults may be more sensitive to the side effects of this medicine.
Common duloxetine side effects may include: